Cell-to-cell communications from short to long distances via extracellular vesicles Biovectors.

The administration of small molecules/drugs via nanoparticles (NPs) has been studied for years. The use of liposomes, micelles, dendrimers, mesoporous silica nanoparticles, gold nanoparticles, superparamagnetic iron oxide nanoparticles (SPION), carbon nanotubes, and quantum dots has achieved good results. However, using NPs has drawbacks such as early elimination, bio-incompatibility, long-term toxicity, and undesired biological effects.

Research on EVs has received a lot of attention, which can be attributed to their unique characteristics and significant involvement in physiological processes. Previous studies have mainly focused on developing simple and effective separation strategies, functionalizing their membrane surfaces, and building multifunctional DDS. EVs can carry many bioactive molecules, such as nucleic acids, proteins, lipids, and sugars, and take on cell-to-cell communications from short to long distances.

The current review explores the biogeny of EVs, their role in the regulation of immunological responses, as well as their contribution to various stages of wound healing. Furthermore, using biomaterials, nanomaterials, and genetically engineered EVs, this paper summarizes existing understanding concerning EVs' potential therapeutic application as a cell-free carrier for healing and tissue regeneration. In addition, basic research routes for maximizing the future clinical potential of EV-based therapies have been outlined.

Check out our recently published article entitled "Extracellular vesicles based bio-vectors in chronic wound healing: Biogenesis and delivery approaches" in "Molecular Therapy: Nucleic Acid" with an IF of 10.18.

Congratulations to my Ph.D. student @Garima for her publication.

You can find the below link to access this amazing article.

https://lnkd.in/dy4KeKta