Stimuli-responsive tailored nanogels for cancer therapy; from bench to personalized treatment

Cancer is a worldwide major public health problem and a leading cause of morbidity and mortality. More than eight million individuals worldwide die from cancer every year. In 2023, the US is expected to have 1.9 million new cases of cancer and 609,360 cancer-related fatalities, or almost 1,670 deaths each day. The global oncology market has been estimated to rise to more than US$ 581.25 billion by 2030 from an expected value of US$ 286.04 billion in 2021, with a predicted cumulative yearly growth rate of 8.2% between 2022 and 2030.

To improve the quality of health in a personalized manner, better control over pharmacologically relevant cargo formulation, organ-specific targeted delivery, and on-demand release of therapeutic agents is crucial. Significant work has been put into designing and developing revolutionary nanotherapeutics approaches for the effective monitoring and personalized treatment of disease. Nanogel (NG) has attracted significant interest because of its tremendous potential in cancer therapy and its environmental stimuli responsiveness. NG is considered a next-generation delivery technology due to its benefits like as size tunability, high loading, stimuli responsiveness, prolonged drug release via in situ gelling mechanisms, stability, and its potential to provide personalized therapy from the investigation of human genes and the genes in various types of cancers and its association with a selective anticancer drug. Stimuli-responsive NGs can be used as smart nanomedicines to detect and treat cancer and can be tuned as personalized medicine as well. This comprehensive review article's major objectives include the challenges of NGs' clinical translation for cancer treatment as well as its early preclinical successes and prospects.

Congratulations to PhD student Prinsy Rana for the Publication of her article in the Journal of Material Chemistry B, by the Royal Society of Chemistry (IF: 7).

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Tumor targeting via active and passive transport mechanism; personalized approach of nanogel towards cancer management; Statistics of data on publication of nanogel in various biomedical fields; predicted oncology market size from 2020 to 2030 USD billion $.